Methanol → 4-[4-(3-Chloro-2,4-difluoroanilino)-7-methoxyquinazolin-6-yl]oxy-1-prop-2-enoylpiperidine-2-carboxylic acid
Reaction equation
[C:1]([CH:2]=[CH2:3])(=[O:4])[N:5]1[CH:6]([C:34](=[O:35])[O:36][CH3:37])[CH2:7][CH:8]([O:11][c:12]2[cH:13][c:14]3[c:15]([NH:24][c:25]4[c:26]([F:33])[c:27]([Cl:32])[c:28]([F:31])[cH:29][cH:30]4)[n:16][cH:17][n:18][c:19]3[cH:20][c:21]2[O:22][CH3:23])[CH2:9][CH2:10]1.[CH3:46][OH:47].[Li+:40].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1.[OH-:39].[OH2:38]>>[C:1]([CH:2]=[CH2:3])(=[O:4])[N:5]1[CH:6]([C:34](=[O:35])[OH:36])[CH2:7][CH:8]([O:11][c:12]2[cH:13][c:14]3[c:15]([NH:24][c:25]4[c:26]([F:33])[c:27]([Cl:32])[c:28]([F:31])[cH:29][cH:30]4)[n:16][cH:17][n:18][c:19]3[cH:20][c:21]2[O:22][CH3:23])[CH2:9][CH2:10]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-a27f8877c8e847858a1d116c29f0d00a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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