Dichloromethane → tert-Butyl 4-((2-methylthiazol-4-yl)methyl)piperazine-1-carboxylate

HRID 951906Notes

Reaction equation

HRID 951906 reaction equation
[C:18](=[O:19])([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[N:25]1[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]1.[CH3:34][CH2:35][O:36][C:37]([CH3:38])=[O:39].[CH:9]([N:10]([CH2:11][CH3:12])[CH:13]([CH3:14])[CH3:15])([CH3:16])[CH3:17].[Cl:1][CH2:2][c:3]1[n:4][c:5]([CH3:8])[s:6][cH:7]1.[Cl:31][CH2:32][Cl:33]>>[CH2:2]([c:3]1[n:4][c:5]([CH3:8])[s:6][cH:7]1)[N:28]1[CH2:27][CH2:26][N:25]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:30][CH2:29]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazole

Product 1

HCID 57897150tert-Butyl 4-((2-methylthiazol-4-yl)methyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-e98fe773ef704a4292aa47be1b3765d7
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…