Chloride → 4-(2-Fluoro-4-methoxyphenyl)-1-(phenylmethyl)-4-piperidinol

HRID 952269Notes

Reaction equation

HRID 952269 reaction equation
[Br:1][c:2]1[c:3]([F:10])[cH:4][c:5]([O:8][CH3:9])[cH:6][cH:7]1.[CH2:16]([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[N:23]1[CH2:24][CH2:25][C:26](=[O:29])[CH2:27][CH2:28]1.[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH:12]([Mg+:13])([CH3:14])[CH3:15].[Cl-:11]>>[c:2]1([C:26]2([OH:29])[CH2:25][CH2:24][N:23]([CH2:16][c:17]3[cH:18][cH:19][cH:20][cH:21][cH:22]3)[CH2:28][CH2:27]2)[c:3]([F:10])[cH:4][c:5]([O:8][CH3:9])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 192201-Benzyl-4-piperidoneHCID 37184441-Bromo-2-fluoro-4-methoxybenzeneHCID 178461726HCID 178461726, compound

Product 1

HCID 670660104-(2-Fluoro-4-methoxyphenyl)-1-(phenylmethyl)-4-piperidinol

Sources & evidence

ORD record
ord-24323e01161046e9aa0bea8310b8796a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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