Water → 1,1-Dimethylethyl 4-(5,7-dihydro-5-methylfuro[3,4-d]pyrimidin-4-yl)-1-piperazinecarboxylate

HRID 952684Notes

Reaction equation

HRID 952684 reaction equation
[C:12](=[O:13])([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[N:19]1[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]1.[CH3:25][N:26]1[CH2:27][CH2:28][CH2:29][C:30]1=[O:31].[CH3:33][CH2:34][O:35][C:36]([CH3:37])=[O:38].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[CH2:8][O:9][CH:10]2[CH3:11].[OH2:32]>>[c:2]1([N:22]2[CH2:21][CH2:20][N:19]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:24][CH2:23]2)[c:3]2[c:4]([n:5][cH:6][n:7]1)[CH2:8][O:9][CH:10]2[CH3:11]

Participants

6

Reactant 5

HCID 962WaterHCID 8857Ethyl AcetateHCID 13387N-methyl-2-pyrrolidoneHCID 143452tert-Butyl piperazine-1-carboxylateHCID 584973354-Chloro-5-methyl-5,7-dihydrofuro[3,4-d]pyrimidine

Product 1

HCID 669855001,1-Dimethylethyl 4-(5,7-dihydro-5-methylfuro[3,4-d]pyrimidin-4-yl)-1-piperazinecarboxylate

Sources & evidence

ORD record
ord-87465b1891d64c90a2dd533c7dc5f03f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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