Tetrahydrofuran → 7-bromo-3-methyl-5-(trifluoromethyl)-1H-indole
Reaction equation
[Al+3:2].[Br:7][c:8]1[cH:9][c:10]([C:19]([F:20])([F:21])[F:22])[cH:11][c:12]2[c:13]([CH:17]=[O:18])[cH:14][nH:15][c:16]12.[CH2:23]1[O:24][CH2:25][CH2:26][CH2:27]1.[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3]>>[Br:7][c:8]1[cH:9][c:10]([C:19]([F:20])([F:21])[F:22])[cH:11][c:12]2[c:13]([CH3:17])[cH:14][nH:15][c:16]12Participants
6
Sources & evidence
- ORD record
- ord-cf0d8a7a687f459cb8822e0b0d428750
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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