Methanol → 5-(3-(1-(1,2,4-Triazin-3-ylamino)-2-methyl-1-oxopropan-2-ylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

HRID 952851Notes

Reaction equation

HRID 952851 reaction equation
[CH3:59][OH:60].[CH:1]([N:2]([CH2:3][CH3:4])[CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9].[F:10][c:11]1[cH:12][cH:13][c:14](-[c:17]2[o:18][c:19]3[c:20]([c:21]2[C:22]([NH:23][CH3:24])=[O:25])[cH:26][c:27](-[c:30]2[cH:31][c:32]([C:33](=[O:34])[NH:35][C:36]([C:37](=[O:38])[OH:39])([CH3:40])[CH3:41])[cH:42][cH:43][cH:44]2)[cH:28][cH:29]3)[cH:15][cH:16]1.[H-:53].[Na+:52].[O:54]=[CH:55][N:56]([CH3:57])[CH3:58].[n:45]1[n:46][c:47]([NH2:51])[n:48][cH:49][cH:50]1>>[F:10][c:11]1[cH:12][cH:13][c:14](-[c:17]2[o:18][c:19]3[c:20]([c:21]2[C:22]([NH:23][CH3:24])=[O:25])[cH:26][c:27](-[c:30]2[cH:31][c:32]([C:33](=[O:34])[NH:35][C:36]([C:37](=[O:39])[NH:51][c:47]4[n:46][n:45][cH:50][cH:49][n:48]4)([CH3:40])[CH3:41])[cH:42][cH:43][cH:44]2)[cH:28][cH:29]3)[cH:15][cH:16]1

Participants

8

Reactant 7

HCID 887MethanolHCID 923Sodium ionHCID 6228DimethylformamideHCID 707153-Amino-1,2,4-triazineHCID 81531DiisopropylethylamineHCID 166653HydrideHCID 592755572-(3-(2-(4-Fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)benzamido)-2-methylpropanoic acid

Product 1

HCID 592755345-(3-(1-(1,2,4-Triazin-3-ylamino)-2-methyl-1-oxopropan-2-ylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Sources & evidence

ORD record
ord-0bbf53af6773499eaba86612e9a98198
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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