Sodium ion → (1RS,2RS)-1-(6-Benzyloxy-1-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-4-(4-methyl-benzyl)-piperidin-4-ol

HRID 95286Notes

Reaction equation

HRID 95286 reaction equation
[Al+3:37].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]2[c:16]([cH:17][cH:18]1)[C:15](=[O:19])[CH:14]([CH2:20][N:21]1[CH2:22][CH2:23][C:24]([CH2:27][c:28]3[cH:29][cH:30][c:31]([CH3:34])[cH:32][cH:33]3)([OH:35])[CH2:25][CH2:26]1)[CH2:13][CH2:12]2.[CH2:45]1[O:46][CH2:47][CH2:48][CH2:49]1.[H-:36].[H-:39].[H-:40].[H-:41].[Li+:38].[Na+:44].[OH-:43].[OH2:42]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]2[c:16]([cH:17][cH:18]1)[CH:15]([OH:19])[CH:14]([CH2:20][N:21]1[CH2:22][CH2:23][C:24]([CH2:27][c:28]3[cH:29][cH:30][c:31]([CH3:34])[cH:32][cH:33]3)([OH:35])[CH2:25][CH2:26]1)[CH2:13][CH2:12]2

Participants

9

Reactant 8

HCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 22628340(RS)-6-Benzyloxy-2-[4-hydroxy-4-(4-methyl-benzyl)-piperidin-1-ylmethyl]-3,4-dihydro-2H-naphthalen-1-one

Product 1

HCID 22628392(1RS,2RS)-1-(6-Benzyloxy-1-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-4-(4-methyl-benzyl)-piperidin-4-ol

Sources & evidence

ORD record
ord-f731e320964140349a4ec56866319102
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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