Dimethylformamide → N-[4-({2-[({4-[(Dimethylamino)methyl]piperidin-1-yl]carbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-N'-(4-fluorophenyl)cyclobutane-1,1-dicarboxamide
Reaction equation
[CH3:46][CH2:47][N:48]([CH2:49][CH3:50])[CH2:51][CH3:52].[CH3:80][N:81]([CH3:82])[CH:83]=[O:84].[F:29][c:30]1[cH:31][cH:32][c:33]([NH:36][C:37](=[O:38])[C:39]2([C:43](=[O:44])[OH:45])[CH2:40][CH2:41][CH2:42]2)[cH:34][cH:35]1.[NH2:1][c:2]1[cH:3][c:4]([F:28])[c:5]([O:6][c:7]2[cH:8][c:9]([NH:13][C:14](=[O:15])[N:16]3[CH2:17][CH2:18][CH:19]([CH2:22][N:23]([CH3:24])[CH3:25])[CH2:20][CH2:21]3)[n:10][cH:11][cH:12]2)[cH:26][cH:27]1.[P-:53]([F:54])([F:55])([F:56])([F:57])([F:58])[F:59].[n:60]1([O:61][P+:62]([N:63]([CH3:64])[CH3:65])([N:66]([CH3:67])[CH3:68])[N:69]([CH3:70])[CH3:71])[c:72]2[cH:73][cH:74][cH:75][cH:76][c:77]2[n:78][n:79]1>>[NH:1]([c:2]1[cH:3][c:4]([F:28])[c:5]([O:6][c:7]2[cH:8][c:9]([NH:13][C:14](=[O:15])[N:16]3[CH2:17][CH2:18][CH:19]([CH2:22][N:23]([CH3:24])[CH3:25])[CH2:20][CH2:21]3)[n:10][cH:11][cH:12]2)[cH:26][cH:27]1)[C:43]([C:39]1([C:37]([NH:36][c:33]2[cH:32][cH:31][c:30]([F:29])[cH:35][cH:34]2)=[O:38])[CH2:40][CH2:41][CH2:42]1)=[O:44]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-5090c6e9f18d42dcac31f8eafcd7e482
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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