Methanol → 6-Chloro-3-[5-chloro-2-(2,2,2-trifluoro-ethoxy)-benzylidene]-1,3-dihydro-indol-2-one

HRID 953317Notes

Reaction equation

HRID 953317 reaction equation
[CH2:27]1[CH2:28][NH:29][CH2:30][CH2:31]1.[CH3:32][OH:33].[Cl:16][c:17]1[cH:18][cH:19][c:20]2[c:24]([cH:25]1)[NH:23][C:22](=[O:26])[CH2:21]2.[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])[c:6]([CH:7]=[O:8])[cH:9]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])[c:6]([CH:7]=[C:21]2[c:20]3[cH:19][cH:18][c:17]([Cl:16])[cH:25][c:24]3[NH:23][C:22]2=[O:26])[cH:9]1

Participants

5

Reactant 4

HCID 887MethanolHCID 31268PyrrolidineHCID 7363446-Chloro-1,3-dihydroindol-2-oneHCID 47709505-Chloro-2-(2,2,2-trifluoroethoxy)benzaldehyde

Product 1

HCID 689603886-Chloro-3-[5-chloro-2-(2,2,2-trifluoro-ethoxy)-benzylidene]-1,3-dihydro-indol-2-one

Sources & evidence

ORD record
ord-643c436d6dba4ad7b9794b58f65fccca
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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