Acetonitrile → 2-Amino-6-methyl-5-[(4-trifluoromethylphenyl)ethynyl]benzonitrile

HRID 954070Notes

Reaction equation

HRID 954070 reaction equation
[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[CH3:31][C:32]#[N:33].[Cu:34][I:35].[F:13][C:14]([c:15]1[cH:16][cH:17][c:18]([I:21])[cH:19][cH:20]1)([F:22])[F:23].[NH2:1][c:2]1[c:3]([C:4]#[N:5])[c:6]([CH3:12])[c:7]([C:10]#[CH:11])[cH:8][cH:9]1>>[NH2:1][c:2]1[c:3]([C:4]#[N:5])[c:6]([CH3:12])[c:7]([C:10]#[C:11][c:18]2[cH:17][cH:16][c:15]([C:14]([F:13])([F:22])[F:23])[cH:20][cH:19]2)[cH:8][cH:9]1

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-HCID 540198812-Amino-5-ethynyl-6-methylbenzonitrile

Product 1

HCID 541158512-Amino-6-methyl-5-[(4-trifluoromethylphenyl)ethynyl]benzonitrile

Sources & evidence

ORD record
ord-703f0b3e75854dc89f4dd9b4488f5a74
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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