Succinic anhydride → Trans-N-[4-[4-Amino-5-(2,3-difluoro-6-methoxy-benzoyl)-pyrimidin-2-ylamino]-cyclohexyl]-succinamic Acid
Reaction equation
[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[NH2:1][c:2]1[n:3][c:4]([NH:20][CH:21]2[CH2:22][CH2:23][CH:24]([NH2:27])[CH2:25][CH2:26]2)[n:5][cH:6][c:7]1[C:8](=[O:9])[c:10]1[c:11]([F:19])[c:12]([F:18])[cH:13][cH:14][c:15]1[O:16][CH3:17].[O:35]=[C:36]1[CH2:37][CH2:38][C:39](=[O:40])[O:41]1.[O:42]1[CH2:43][CH2:44][CH2:45][CH2:46]1>>[NH2:1][c:2]1[n:3][c:4]([NH:20][CH:21]2[CH2:22][CH2:23][CH:24]([NH:27][C:39]([CH2:38][CH2:37][C:36](=[O:35])[OH:41])=[O:40])[CH2:25][CH2:26]2)[n:5][cH:6][c:7]1[C:8](=[O:9])[c:10]1[c:11]([F:19])[c:12]([F:18])[cH:13][cH:14][c:15]1[O:16][CH3:17]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-44291c24ad27463cac6cb9834a8a0a41
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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