Acetate → 4-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([C:21]([F:22])([F:23])[F:24])[cH:18][c:19]2[Cl:20])[CH2:12][CH2:13]1.[CH3:56][B:57]([OH:58])[OH:59].[CH:25]1([P:26]([CH:27]2[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]2)[c:33]2[cH:34][cH:35][cH:36][cH:37][c:38]2-[c:39]2[c:40]([O:41][CH3:42])[cH:43][cH:44][cH:45][c:46]2[O:47][CH3:48])[CH2:49][CH2:50][CH2:51][CH2:52][CH2:53]1.[F-:54].[K+:55].[O-:61][C:62]([CH3:63])=[O:64].[O-:65][C:66]([CH3:67])=[O:68].[O:70]1[CH2:71][CH2:72][CH2:73][CH2:74]1.[OH2:69].[Pd+2:60]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][cH:16][c:17]([C:21]([F:22])([F:23])[F:24])[cH:18][c:19]2[CH3:25])[CH2:12][CH2:13]1Participants
10
Reactant 9
HCID 175Acetate2×
HCID 813Potassium Cation
HCID 962Water
HCID 8028Tetrahydrofuran
HCID 28179Fluoride Ion
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 139377Methylboronic Acid
HCID 112698722-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
HCID 573664161-Tert-butyloxycarbonyl-4-(3-chloro-5-(trifluoromethyl)pyridin-2-YL)piperazineProduct 1
Sources & evidence
- ORD record
- ord-5b91faac3bfb43969d8412c023c21469
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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