Tetrahydrofuran → ethyl 6-chloro-7-[(4-methylpyridin-2-yl)methyl]-2-(trifluoromethyl)-2H-chromene-3-carboxylate

HRID 954725Notes

Reaction equation

HRID 954725 reaction equation
[Br:10][CH2:11][c:12]1[c:13]([Cl:31])[cH:14][c:15]2[c:20]([cH:21]1)[O:19][CH:18]([C:22]([F:23])([F:24])[F:25])[C:17]([C:26](=[O:27])[O:28][CH2:29][CH3:30])=[CH:16]2.[Br:1][Mg:2][c:3]1[n:4][cH:5][cH:6][c:7]([CH3:9])[cH:8]1.[CH2:73]1[O:74][CH2:75][CH2:76][CH2:77]1.[Pd:32]([Cl:33])[Cl:34].[c:35]1([P:36]([c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[cH:49][cH:50][cH:51][cH:52][cH:53]1.[c:54]1([P:55]([c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[cH:68][cH:69][cH:70][cH:71][cH:72]1>>[c:3]1([CH2:11][c:12]2[c:13]([Cl:31])[cH:14][c:15]3[c:20]([cH:21]2)[O:19][CH:18]([C:22]([F:23])([F:24])[F:25])[C:17]([C:26](=[O:27])[O:28][CH2:29][CH3:30])=[CH:16]3)[n:4][cH:5][cH:6][c:7]([CH3:9])[cH:8]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 69517129ethyl 7-(bromomethyl)-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylateHCID 178428553HCID 178428553, compound

Product 1

HCID 69519058ethyl 6-chloro-7-[(4-methylpyridin-2-yl)methyl]-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Sources & evidence

ORD record
ord-4bc2834de61d4f77a39374cafa2630a7
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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