Acetonitrile → Ethyl 2-amino-5-chloro-1,3-thiazole-4-carboxylate

HRID 955359Notes

Reaction equation

HRID 955359 reaction equation
[CH3:20][C:21]#[N:22].[CH3:23][CH2:24][O:25][C:26]([CH3:27])=[O:28].[Cl:12][N:13]1[C:14](=[O:15])[CH2:16][CH2:17][C:18]1=[O:19].[NH2:1][c:2]1[s:3][cH:4][c:5]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[n:6]1>>[NH2:1][c:2]1[s:3][c:4]([Cl:12])[c:5]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[n:6]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 8857Ethyl AcetateHCID 31398ChlorosuccinimideHCID 73216Ethyl 2-aminothiazole-4-carboxylate

Product 1

HCID 21780304Ethyl 2-amino-5-chloro-1,3-thiazole-4-carboxylate

Sources & evidence

ORD record
ord-48a09f52ee0c4e1d9bcb29805c0f709a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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