Dimethyl Sulfoxide → Tert-butyl 4-(3-oxopropyl)piperidine-1-carboxylate

HRID 955371Notes

Reaction equation

HRID 955371 reaction equation
[C:11]([CH3:12])([CH3:13])([CH3:14])[O:15][C:16](=[O:17])[N:18]1[CH2:19][CH2:20][CH:21]([CH2:24][CH2:25][CH2:26][OH:27])[CH2:22][CH2:23]1.[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[CH3:7][S:8]([CH3:9])=[O:10].[Cl:1][C:2]([C:3]([Cl:4])=[O:5])=[O:6].[Cl:35][CH2:36][Cl:37]>>[C:11]([CH3:12])([CH3:13])([CH3:14])[O:15][C:16](=[O:17])[N:18]1[CH2:19][CH2:20][CH:21]([CH2:24][CH2:25][CH:26]=[O:27])[CH2:22][CH2:23]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 2800739tert-Butyl 4-(3-hydroxypropyl)tetrahydro-1(2h)-pyridinecarboxylate

Product 1

HCID 10657745Tert-butyl 4-(3-oxopropyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-7b33dbaa56f548689eb122b296c9f1d5
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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