Tetrahydrofuran → 1-(Tetrahydro-2H-pyran-2-yl)-5-(3,3,3-trifluoroprop-1-yn-1-yl)-1H-indazole

HRID 955982Notes

Reaction equation

[Br:9][C:10](=[CH2:11])[C:12]([F:13])([F:14])[F:15].[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH3:16][N:17]([CH3:18])[CH2:19][CH2:20][N:21]([CH3:22])[CH3:23].[CH3:2][CH:3]([N-:4][CH:5]([CH3:6])[CH3:7])[CH3:8].[I:24][c:25]1[cH:26][c:27]2[cH:28][n:29][n:30]([CH:34]3[O:35][CH2:36][CH2:37][CH2:38][CH2:39]3)[c:31]2[cH:32][cH:33]1.[Li+:1].[cH:45]1[cH:46][cH:47][c:48]([P:49]([Pd:50]([P:51]([c:52]2[cH:53][cH:54][cH:55][cH:56][cH:57]2)([c:58]2[cH:59][cH:60][cH:61][cH:62][cH:63]2)[c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)([P:70]([c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)([c:77]2[cH:78][cH:79][cH:80][cH:81][cH:82]2)[c:83]2[cH:84][cH:85][cH:86][cH:87][cH:88]2)[P:89]([c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)([c:96]2[cH:97][cH:98][cH:99][cH:100][cH:101]2)[c:102]2[cH:103][cH:104][cH:105][cH:106][cH:107]2)([c:108]2[cH:109][cH:110][cH:111][cH:112][cH:113]2)[c:114]2[cH:115][cH:116][cH:117][cH:118][cH:119]2)[cH:120][cH:121]1>>[C:10](#[C:11][c:25]1[cH:26][c:27]2[cH:28][n:29][n:30]([CH:34]3[O:35][CH2:36][CH2:37][CH2:38][CH2:39]3)[c:31]2[cH:32][cH:33]1)[C:12]([F:13])([F:14])[F:15]