Bicarbonate Ion → 2-(T-Butyldimethylsilyloxy)-4-bromoanisole

HRID 956023Notes

Reaction equation

HRID 956023 reaction equation
[Br:10][c:11]1[cH:12][cH:13][c:14]([O:18][CH3:19])[c:15]([OH:17])[cH:16]1.[C:20]([CH3:21])([CH3:22])([CH3:23])[Si:24]([CH3:25])([CH3:26])[Cl:27].[CH2:1]([N:2]([CH:3]([CH3:4])[CH3:5])[CH:6]([CH3:7])[CH3:8])[CH3:9].[Na+:32].[O-:28][C:29]([OH:30])=[O:31].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37].[OH2:38]>>[Br:10][c:11]1[cH:12][cH:13][c:14]([O:18][CH3:19])[c:15]([O:17][Si:24]([C:20]([CH3:21])([CH3:22])[CH3:23])([CH3:25])[CH3:26])[cH:16]1

Participants

8

Reactant 7

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 28928tert-Butyldimethylsilyl chlorideHCID 81531DiisopropylethylamineHCID 1422285-Bromo-2-methoxyphenol

Product 1

HCID 109800492-(T-Butyldimethylsilyloxy)-4-bromoanisole

Sources & evidence

ORD record
ord-55446111ca894cd4ac3fdbc495b99ebc
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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