Acetic Acid → Ethyl 2-cyano-5-phenyl-1,3-thiazole-4-carboxylate

HRID 956145Notes

Reaction equation

HRID 956145 reaction equation
[C-:30]#[N:31].[CH3:38][CH2:39][O:40][C:41]([CH3:42])=[O:43].[CH3:44][C:45](=[O:46])[OH:47].[Cu:27][C:28]#[N:29].[N:23]([O-:24])=[O:25].[NH2:1][c:2]1[s:3][c:4](-[c:12]2[cH:13][cH:14][cH:15][cH:16][cH:17]2)[c:5]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[n:6]1.[Na+:26].[Na+:32].[Na+:37].[O-:33][C:34]([OH:35])=[O:36].[S:18](=[O:19])(=[O:20])([OH:21])[OH:22]>>[c:2]1([C:28]#[N:29])[s:3][c:4](-[c:12]2[cH:13][cH:14][cH:15][cH:16][cH:17]2)[c:5]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[n:6]1

Participants

10

Reactant 9

HCID 176Acetic AcidHCID 769Bicarbonate IonHCID 923Sodium ion3×HCID 946NitriteHCID 1118Sulfuric AcidHCID 5975CyanideHCID 8857Ethyl AcetateHCID 12603728Ethyl 2-amino-5-phenyl-1,3-thiazole-4-carboxylateHCID 178418546HCID 178418546, compound

Product 1

HCID 59291286Ethyl 2-cyano-5-phenyl-1,3-thiazole-4-carboxylate

Sources & evidence

ORD record
ord-eee69a7250ba4baba59132e2c044d277
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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