Water → Ethyl 6-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidin-4,2'-inden]-5'-ylamino)pyrimidine-4-carboxylate

HRID 956513Notes

Reaction equation

HRID 956513 reaction equation
[CH:18]([N:19]([CH2:20][CH3:21])[CH:22]([CH3:23])[CH3:24])([CH3:25])[CH3:26].[Cl:27][c:28]1[cH:29][c:30]([C:34](=[O:35])[O:36][CH2:37][CH3:38])[n:31][cH:32][n:33]1.[NH2:1][c:2]1[cH:3][c:4]2[c:15]([cH:16][cH:17]1)[CH2:14][C:6]1([CH2:5]2)[N:7]([CH3:13])[C:8](=[O:12])[NH:9][C:10]1=[O:11].[O:39]=[CH:40][N:41]([CH3:42])[CH3:43].[OH2:44]>>[NH:1]([c:2]1[cH:3][c:4]2[c:15]([cH:16][cH:17]1)[CH2:14][C:6]1([CH2:5]2)[N:7]([CH3:13])[C:8](=[O:12])[NH:9][C:10]1=[O:11])[c:28]1[cH:29][c:30]([C:34](=[O:35])[O:36][CH2:37][CH3:38])[n:31][cH:32][n:33]1

Participants

6

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 18440306(-)-5'-Amino-3-methyl-spiro[imidazolidine-4,2'-indane]-2,5-dioneHCID 22756838Ethyl 6-chloropyrimidine-4-carboxylate

Product 1

HCID 58117486Ethyl 6-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidin-4,2'-inden]-5'-ylamino)pyrimidine-4-carboxylate

Sources & evidence

ORD record
ord-6a92ddb13ba04d7c9039e2f3507f619e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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