Dichloromethane → 4-methyl-N3-(3-pyrimidin-4-yl-pyridin-2-yl)-benzene-1,3-diamine

HRID 956520Notes

Reaction equation

HRID 956520 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[cH:9][c:10]([NH:15][c:16]2[n:17][cH:18][cH:19][cH:20][c:21]2-[c:22]2[n:23][cH:24][n:25][cH:26][cH:27]2)[c:11]([CH3:14])[cH:12][cH:13]1)([CH3:5])([CH3:6])[CH3:28].[CH3:39][CH2:40][O:41][C:42]([CH3:43])=[O:44].[Cl:29][CH2:30][Cl:31].[F:32][C:33]([F:34])([F:35])[C:36]([OH:37])=[O:38]>>[NH2:7][c:8]1[cH:9][c:10]([NH:15][c:16]2[n:17][cH:18][cH:19][cH:20][c:21]2-[c:22]2[n:23][cH:24][n:25][cH:26][cH:27]2)[c:11]([CH3:14])[cH:12][cH:13]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 8857Ethyl AcetateHCID 66970434[4-Methyl-3-(3-pyrimidin-4-yl-pyridin-2-ylamino)-phenyl]-carbamic acid tert-butyl ester

Product 1

HCID 583962724-methyl-N3-(3-pyrimidin-4-yl-pyridin-2-yl)-benzene-1,3-diamine

Sources & evidence

ORD record
ord-b93f870dc268405382fc22749a58dd10
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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