Dimethyl Sulfoxide → N-[5-[[4-(hydroxymethyl)-3-(trifluoromethyl)pyrazol-1-yl]methyl]-2,3-dihydro-1H-inden-2-yl]methanesulfonamide

HRID 956638Notes

Reaction equation

HRID 956638 reaction equation
[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[CH3:30][S:31]([Cl:32])(=[O:33])=[O:34].[CH3:40][S:41]([CH3:42])=[O:43].[NH2:1][CH:2]1[CH2:3][c:4]2[cH:5][cH:6][c:7]([CH2:11][n:12]3[n:13][c:14]([C:19]([F:20])([F:21])[F:22])[c:15]([CH2:17][OH:18])[cH:16]3)[cH:8][c:9]2[CH2:10]1.[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1>>[NH:1]([CH:2]1[CH2:3][c:4]2[cH:5][cH:6][c:7]([CH2:11][n:12]3[n:13][c:14]([C:19]([F:20])([F:21])[F:22])[c:15]([CH2:17][OH:18])[cH:16]3)[cH:8][c:9]2[CH2:10]1)[S:31]([CH3:30])(=[O:33])=[O:34]

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 67088047[1-[(2-amino-2,3-dihydro-1H-inden-5-yl)methyl]-3-(trifluoromethyl)pyrazol-4-yl]methanol

Product 1

HCID 67088077N-[5-[[4-(hydroxymethyl)-3-(trifluoromethyl)pyrazol-1-yl]methyl]-2,3-dihydro-1H-inden-2-yl]methanesulfonamide

Sources & evidence

ORD record
ord-1e4c2907af8a48bab9765516dc4788d2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…