Hydrochloric Acid → 3-Fluoro-4-(4-methylpiperazin-1-yl)benzene-1,2-diamine

HRID 956825Notes

Reaction equation

HRID 956825 reaction equation
[CH3:28][CH2:29][OH:30].[ClH:21].[F:1][c:2]1[c:3]([NH2:18])[c:4]([N+:15]([O-:16])=[O:17])[cH:5][cH:6][c:7]1[N:8]1[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH2:13]1.[NH2:19][OH:20].[cH:22]1[cH:23][cH:24][n:25][cH:26][cH:27]1>>[F:1][c:2]1[c:3]([NH2:18])[c:4]([NH2:15])[cH:5][cH:6][c:7]1[N:8]1[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 787HydroxylamineHCID 1049PyridineHCID 220408162-Fluoro-3-(4-methyl-piperazin-1-yl)-6-nitro-phenylamine

Product 1

HCID 220407433-Fluoro-4-(4-methylpiperazin-1-yl)benzene-1,2-diamine

Sources & evidence

ORD record
ord-5604519cf518481a997584f4de1f2d61
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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