Tetrahydrofuran → tert-butyl N-[1-hydroxy-4-methyl-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamate

HRID 956858Notes

Reaction equation

HRID 956858 reaction equation
[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:11][C:12]([CH3:13])([O:14][C:15](=[O:16])[NH:17][CH:18]([CH2:19][CH:20]([CH3:21])[CH3:22])[CH:23]=[O:24])[CH3:25].[CH3:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1.[cH:6]1[cH:7][s:8][cH:9][n:10]1>>[cH:6]1[cH:7][s:8][c:9]([CH:23]([CH:18]([NH:17][C:15]([O:14][C:12]([CH3:11])([CH3:13])[CH3:25])=[O:16])[CH2:19][CH:20]([CH3:21])[CH3:22])[OH:24])[n:10]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8058HexaneHCID 9256ThiazoleHCID 546109tert-butyl N-(4-methyl-1-oxopentan-2-yl)carbamateHCID 178418339Butyllithium

Product 1

HCID 14796004tert-butyl N-[1-hydroxy-4-methyl-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamate

Sources & evidence

ORD record
ord-07b12053599e49a49cc1b74a7cfa728a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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