Sodium ion → 1-Cyclopentyl-3-(2,6-difluoro-3,5-dimethoxy-phenyl)-7-methylsulfanyl-4H-pyrimido[4,5-D]pyrimidin-2-one

HRID 956930Notes

Reaction equation

HRID 956930 reaction equation
[C:31](=[O:32])([n:33]1[cH:34][cH:35][n:36][cH:37]1)[n:38]1[cH:39][cH:40][n:41][cH:42]1.[CH:1]1([NH:6][c:7]2[n:8][c:9]([S:27][CH3:28])[n:10][cH:11][c:12]2[CH2:13][NH:14][c:15]2[c:16]([F:26])[c:17]([O:24][CH3:25])[cH:18][c:19]([O:22][CH3:23])[c:20]2[F:21])[CH2:2][CH2:3][CH2:4][CH2:5]1.[H-:29].[Na+:30].[O:43]1[CH2:44][CH2:45][CH2:46][CH2:47]1>>[CH:1]1([N:6]2[c:7]3[n:8][c:9]([S:27][CH3:28])[n:10][cH:11][c:12]3[CH2:13][N:14]([c:15]3[c:16]([F:26])[c:17]([O:24][CH3:25])[cH:18][c:19]([O:22][CH3:23])[c:20]3[F:21])[C:31]2=[O:32])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 8028TetrahydrofuranHCID 682631,1'-CarbonyldiimidazoleHCID 166653HydrideHCID 18444835Cyclopentyl-(5-[(2,6-difluoro-3,5-dimethoxy-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl)-amine

Product 1

HCID 184446921-Cyclopentyl-3-(2,6-difluoro-3,5-dimethoxy-phenyl)-7-methylsulfanyl-4H-pyrimido[4,5-D]pyrimidin-2-one

Sources & evidence

ORD record
ord-4d52c651761e47158a45893587b8d75b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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