Hydrochloric Acid → N-[4-(cyclopropylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-1-[[2-methoxy-6-(trifluoromethyl)phenyl]methyl]-5-oxopyrrolidine-2-carboxamide
Reaction equation
[CH3:10][O:11][c:12]1[c:13]([CH2:14][N:15]2[CH:16]([C:21](=[O:22])[OH:23])[CH2:17][CH2:18][C:19]2=[O:20])[c:24]([C:28]([F:29])([F:30])[F:31])[cH:25][cH:26][cH:27]1.[CH:1]([N:2]([CH2:3][CH3:4])[CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9].[Cl:74][CH2:75][Cl:76].[ClH:32].[NH2:33][CH:34]([CH:35]([C:36](=[O:37])[NH:38][CH:39]1[CH2:40][CH2:41]1)[OH:42])[CH2:43][c:44]1[cH:45][cH:46][cH:47][cH:48][cH:49]1.[OH2:77].[P-:50]([F:51])([F:52])([F:53])([F:54])([F:55])[F:56].[n:57]1([O:58][C:59]([N:60]([CH3:61])[CH3:62])=[N+:63]([CH3:64])[CH3:65])[c:66]2[n:67][cH:68][cH:69][cH:70][c:71]2[n:72][n:73]1>>[CH3:10][O:11][c:12]1[c:13]([CH2:14][N:15]2[CH:16]([C:21](=[O:22])[NH:33][CH:34]([CH:35]([C:36](=[O:37])[NH:38][CH:39]3[CH2:40][CH2:41]3)[OH:42])[CH2:43][c:44]3[cH:45][cH:46][cH:47][cH:48][cH:49]3)[CH2:17][CH2:18][C:19]2=[O:20])[c:24]([C:28]([F:29])([F:30])[F:31])[cH:25][cH:26][cH:27]1Participants
9
Reactant 8
HCID 313Hydrochloric Acid
HCID 962Water
HCID 6344Dichloromethane
HCID 9886Hexafluorophosphate
HCID 81531Diisopropylethylamine
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium
HCID 666447213-amino-N-cyclopropyl-2-hydroxy-4-phenylbutanamide
HCID 666448541-[[2-Methoxy-6-(trifluoromethyl)phenyl]methyl]-5-oxopyrrolidine-2-carboxylic acidProduct 1
Sources & evidence
- ORD record
- ord-ff15e8716976481892c82d9828721702
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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