Dimethylformamide → Tert-butyl 4-(4-methoxycarbonylphenyl)-1,4-diazepane-1-carboxylate

HRID 957061Notes

Reaction equation

HRID 957061 reaction equation
[C:26](=[O:27])([O-:28])[O-:29].[C:32]([CH:33]1[CH2:34][CH2:35][CH2:36][CH2:37][C:38]1=[O:39])(=[O:40])[CH3:41].[Cs+:30].[Cs+:31].[Cu:47]([I:48])[I:49].[I:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[O:8][CH3:9])[cH:10][cH:11]1.[N:12]1([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:13][CH2:14][NH:15][CH2:16][CH2:17][CH2:18]1.[O:42]=[CH:43][N:44]([CH3:45])[CH3:46]>>[c:2]1([N:15]2[CH2:14][CH2:13][N:12]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:18][CH2:17][CH2:16]2)[cH:3][cH:4][c:5]([C:6](=[O:7])[O:8][CH3:9])[cH:10][cH:11]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 134002-AcetylcyclohexanoneHCID 19660Carbonate IonHCID 69273Methyl 4-iodobenzoateHCID 83717Copper iodideHCID 104967Cesium cation2×HCID 2756058Tert-butyl 1,4-diazepane-1-carboxylate

Product 1

HCID 57362684Tert-butyl 4-(4-methoxycarbonylphenyl)-1,4-diazepane-1-carboxylate

Sources & evidence

ORD record
ord-564c1a0a569942498a0ba76cb50cedf4
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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