Dichloromethane → 1-(4-Cyclobutylmethyl-piperazin-1-yl)-2-[2-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-phenyl]-ethanone

HRID 957295Notes

Reaction equation

HRID 957295 reaction equation
[CH3:25][n:26]1[n:27][cH:28][c:29]2[c:35]1[NH:34][c:33]1[c:32]([cH:39][cH:38][cH:37][cH:36]1)[NH:31][CH2:30]2.[CH3:49][N:50]([c:51]1[cH:52][cH:53][n:54][cH:55][cH:56]1)[CH3:57].[CH:1]1([CH2:5][N:6]2[CH2:7][CH2:8][N:9]([C:12]([CH2:13][c:14]3[c:15]([CH3:23])[cH:16][c:17]([C:18](=[O:19])[OH:20])[cH:21][cH:22]3)=[O:24])[CH2:10][CH2:11]2)[CH2:2][CH2:3][CH2:4]1.[CH:40]([N:41]([CH2:42][CH3:43])[CH:44]([CH3:45])[CH3:46])([CH3:47])[CH3:48].[Cl:58][CH2:59][Cl:60]>>[CH:1]1([CH2:5][N:6]2[CH2:7][CH2:8][N:9]([C:12]([CH2:13][c:14]3[c:15]([CH3:23])[cH:16][c:17]([C:18](=[O:19])[N:31]4[CH2:30][c:29]5[cH:28][n:27][n:26]([CH3:25])[c:35]5[NH:34][c:33]5[c:32]4[cH:39][cH:38][cH:37][cH:36]5)[cH:21][cH:22]3)=[O:24])[CH2:10][CH2:11]2)[CH2:2][CH2:3][CH2:4]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 142844-(Dimethylamino)pyridineHCID 81531DiisopropylethylamineHCID 575554124-[2-(4-Cyclobutylmethyl-piperazin-1-yl)-2-oxo-ethyl]-3-methyl-benzoic AcidHCID 1357419771-Methyl-1,4,5,10-tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine

Product 1

HCID 1361284321-(4-Cyclobutylmethyl-piperazin-1-yl)-2-[2-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-phenyl]-ethanone

Sources & evidence

ORD record
ord-507e3488392a47fe95795409d4620c4f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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