Chloroacetonitrile → Tert-butyl 4-(cyanomethyl)piperazine-1-carboxylate

HRID 957464Notes

Reaction equation

HRID 957464 reaction equation
[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1.[CH2:18]1[O:19][CH2:20][CH2:21][CH2:22]1.[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[Cl:14][CH2:15][C:16]#[N:17]>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:15][C:16]#[N:17])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 7856ChloroacetonitrileHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 21936030Tert-butyl 4-(cyanomethyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-3380e26d0bb542d18aec6ee3c83659a1
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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