Dimethylformamide → (1-Methoxyethyl)(trimethyl)silane

HRID 957482Notes

Reaction equation

HRID 957482 reaction equation
[Br:36][CH2:37][C:38](=[O:39])[NH2:40].[Br:9][c:10]1[cH:11][cH:12][c:13]2[c:17]([cH:18]1)[NH:16][C:15](=[O:19])[C:14]21[CH:20]([C:33](=[CH2:34])[CH3:35])[NH:21][C:22](=[O:32])[CH2:23][CH:24]1[c:25]1[cH:26][c:27]([Cl:31])[cH:28][cH:29][cH:30]1.[C:41](=[O:42])([O-:43])[O-:44].[CH3:1][O:2][CH:3]([CH3:4])[Si:5]([CH3:6])([CH3:7])[CH3:8].[CH3:47][CH2:48][O:49][C:50](=[O:51])[CH3:52].[Cs+:45].[Cs+:46].[O:53]=[CH:54][N:55]([CH3:56])[CH3:57]>>[Br:9][c:10]1[cH:11][cH:12][c:13]2[c:17]([cH:18]1)[NH:16][C:15](=[O:19])[C:14]21[CH:20]([C:33](=[CH2:34])[CH3:35])[N:21]([CH2:37][C:38](=[O:39])[NH2:40])[C:22](=[O:32])[CH2:23][CH:24]1[c:25]1[cH:26][c:27]([Cl:31])[cH:28][cH:29][cH:30]1.[CH3:1][O:2][CH:3]([CH3:4])[Si:5]([CH3:6])([CH3:7])[CH3:8]

Participants

9

Reactant 7

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 696322-BromoacetamideHCID 104967Cesium cation2×HCID 22400412(1-Methoxyethyl)(trimethyl)silaneHCID 76568131HCID 76568131, compound

Product 2

HCID 22400412(1-Methoxyethyl)(trimethyl)silaneHCID 765681142-[6-bromo-4'-(3-chlorophenyl)-2,6'-dioxo-2'-prop-1-en-2-ylspiro[1H-indole-3,3'-piperidine]-1'-yl]acetamide

Sources & evidence

ORD record
ord-2c7b32afefdb4cad94cb77571263024f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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