Phosphorus oxychloride → 4-Chloro-2-chloromethyl-7-(3-trifluoromethyl-pyridin-2-yl)-quinazoline
Reaction equation
[Cl:1][CH2:2][c:3]1[n:4][c:5]2[cH:6][c:7](-[c:14]3[n:15][cH:16][cH:17][cH:18][c:19]3[C:20]([F:21])([F:22])[F:23])[cH:8][cH:9][c:10]2[c:11](=[O:13])[nH:12]1.[P:24]([Cl:25])([Cl:26])([Cl:27])=[O:28]>>[Cl:1][CH2:2][c:3]1[n:4][c:5]2[cH:6][c:7](-[c:14]3[n:15][cH:16][cH:17][cH:18][c:19]3[C:20]([F:21])([F:22])[F:23])[cH:8][cH:9][c:10]2[c:11]([Cl:26])[n:12]1Participants
3
Sources & evidence
- ORD record
- ord-00fa39a5c0dd444b8c48c62e0b1905ef
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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