Tetrahydrofuran → tert-butyl N-[3-hydroxy-4-[[3-(2-hydroxypropan-2-yl)phenyl]methylamino]-1-phenylbutan-2-yl]carbamate

HRID 957742Notes

Reaction equation

HRID 957742 reaction equation
[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:38][CH2:39][O:40][C:41]([CH3:42])=[O:43].[NH2:1][CH2:2][CH:3]([CH:4]([CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[NH:12][C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[OH:20].[OH:21][C:22]([CH3:23])([CH3:24])[c:25]1[cH:26][c:27]([CH:28]=[O:29])[cH:30][cH:31][cH:32]1>>[NH:1]([CH2:2][CH:3]([CH:4]([CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[NH:12][C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[OH:20])[CH2:28][c:27]1[cH:26][c:25]([C:22]([OH:21])([CH3:23])[CH3:24])[cH:32][cH:31][cH:30]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 11065838tert-butyl N-(4-amino-3-hydroxy-1-phenylbutan-2-yl)carbamateHCID 866474433-(2-Hydroxypropan-2-yl)benzaldehyde

Product 1

HCID 72328655tert-butyl N-[3-hydroxy-4-[[3-(2-hydroxypropan-2-yl)phenyl]methylamino]-1-phenylbutan-2-yl]carbamate

Sources & evidence

ORD record
ord-e4981f2ab4064e04a2e2d6e3f1c86ab5
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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