Hydrochloric Acid → [5-(1-Isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone

HRID 958411Notes

Reaction equation

HRID 958411 reaction equation
[CH3:30][CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36].[CH3:37][S:38]([Cl:39])(=[O:40])=[O:41].[CH:3]([CH3:4])([CH3:5])[N:6]1[CH2:7][CH2:8][CH:9]([O:12][c:13]2[cH:14][c:15]3[cH:16][c:17]([C:22](=[O:23])[N:24]4[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]4)[nH:18][c:19]3[cH:20][cH:21]2)[CH2:10][CH2:11]1.[Cl:42][CH2:43][Cl:44].[ClH:1].[ClH:2]>>[CH:3]([CH3:4])([CH3:5])[N:6]1[CH2:7][CH2:8][CH:9]([O:12][c:13]2[cH:14][c:15]3[cH:16][c:17]([C:22](=[O:23])[N:24]4[CH2:25][CH2:26][N:27]([S:38]([CH3:37])(=[O:40])=[O:41])[CH2:28][CH2:29]4)[nH:18][c:19]3[cH:20][cH:21]2)[CH2:10][CH2:11]1

Participants

6

Reactant 5

HCID 313Hydrochloric Acid2×HCID 6344DichloromethaneHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 68565071piperazin-1-yl-[5-(1-propan-2-ylpiperidin-4-yl)oxy-1H-indol-2-yl]methanone

Product 1

HCID 24958929[5-(1-Isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone

Sources & evidence

ORD record
ord-c70702c8ec274eefa470b52f421b78c2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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