Potassium Cation → {(5-Chloro-benzo[b]thiophen-3-yl)-[2-(3,4-difluoro-phenyl)-vinylcarbamoyl]-methyl}-methyl-phosphinic acid ethyl ester
Reaction equation
[Br:33][CH:34]=[CH:35][c:36]1[cH:37][c:38]([F:43])[c:39]([F:42])[cH:40][cH:41]1.[CH2:1]([CH3:2])[O:3][P:4](=[O:5])([CH3:6])[CH:7]([c:8]1[c:9]2[c:10]([s:11][cH:12]1)[cH:13][cH:14][c:15]([Cl:17])[cH:16]2)[C:18]([NH2:19])=[O:20].[CH3:27][NH:28][CH2:29][CH2:30][NH:31][CH3:32].[CH3:46][N:47]([CH3:48])[C:49](=[O:50])[CH3:51].[Cu:44][I:45].[K+:21].[K+:22].[O-:23][C:24]([O-:25])=[O:26]>>[CH2:1]([CH3:2])[O:3][P:4](=[O:5])([CH3:6])[CH:7]([c:8]1[c:9]2[c:10]([s:11][cH:12]1)[cH:13][cH:14][c:15]([Cl:17])[cH:16]2)[C:18]([NH:19][CH:34]=[CH:35][c:36]1[cH:37][c:38]([F:43])[c:39]([F:42])[cH:40][cH:41]1)=[O:20]Participants
8
Reactant 7
HCID 813Potassium Cation2×
HCID 8070N,N'-Dimethylethylenediamine
HCID 19660Carbonate Ion
HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
HCID 31374Dimethylacetamide
HCID 44228969Ethyl (2-amino-1-(5-chlorobenzo[b]thiophen-3-yl)-2-oxoethyl)(methyl)phosphinate
HCID 533953134-(2-Bromo-vinyl)-1,2-difluoro-benzeneProduct 1
Sources & evidence
- ORD record
- ord-388bd57a1d22475f8a7ba5a7e2dfb018
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
Loading…