Water → [2-Fluoro-4-(4-[1,2,3]triazol-1-yl-butyl)-phenyl]-carbamic acid tert-butyl ester

HRID 959700Notes

Reaction equation

HRID 959700 reaction equation
[C:15]([CH3:16])([CH3:17])([CH3:18])[O:19][C:20]([NH:21][c:22]1[c:23]([F:29])[cH:24][c:25]([Br:28])[cH:26][cH:27]1)=[O:30].[C:31](=[O:32])([O-:33])[O-:34].[CH2:10]1[O:11][CH2:12][CH2:13][CH2:14]1.[CH2:1]([CH2:2][CH:3]=[CH2:4])[n:5]1[n:6][n:7][cH:8][cH:9]1.[Cs+:35].[Cs+:36].[O:37]=[CH:38][N:39]([CH3:40])[CH3:41].[OH2:42]>>[CH2:1]([CH2:2][CH2:3][CH2:4][c:25]1[cH:24][c:23]([F:29])[c:22]([NH:21][C:20]([O:19][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:30])[cH:27][cH:26]1)[n:5]1[n:6][n:7][cH:8][cH:9]1

Participants

8

Reactant 7

HCID 962WaterHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 190682081-but-3-enyl-1H-[1,2,3]triazoleHCID 22736228tert-butyl N-(4-bromo-2-fluorophenyl)carbamate

Product 1

HCID 69220904[2-Fluoro-4-(4-[1,2,3]triazol-1-yl-butyl)-phenyl]-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-1cfe0636ca5d4920932fcec6ccd9d6d5
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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