Aniline → 4,6-Dichloro-N-phenyl-2-pyrimidinamine

HRID 960314Notes

Reaction equation

HRID 960314 reaction equation
[CH:17]([N:18]([CH2:19][CH3:20])[CH:21]([CH3:22])[CH3:23])([CH3:24])[CH3:25].[Cl:1][c:2]1[n:3][c:4]([Cl:9])[cH:5][c:6]([Cl:8])[n:7]1.[NH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[O:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1>>[c:2]1([NH:10][c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)[n:3][c:4]([Cl:9])[cH:5][c:6]([Cl:8])[n:7]1

Participants

5

Reactant 4

HCID 6115AnilineHCID 8028TetrahydrofuranHCID 773782,4,6-TrichloropyrimidineHCID 81531Diisopropylethylamine

Product 1

HCID 6171324,6-Dichloro-N-phenyl-2-pyrimidinamine

Sources & evidence

ORD record
ord-c5ea24ea40ec4ff593865f240ad2ca4b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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