Dimethylformamide → (1-Methoxyethyl)(trimethyl)silane

HRID 960353Notes

Reaction equation

HRID 960353 reaction equation
[CH3:1][O:2][CH:3]([CH3:4])[Si:5]([CH3:6])([CH3:7])[CH3:8].[CH3:52][N:53]([CH3:54])[CH:55]=[O:56].[Cl:47][CH2:48][CH2:49][CH2:50][I:51].[Cl:9][c:10]1[cH:11][cH:12][c:13]2[c:17]([cH:18]1)[NH:16][C:15](=[O:19])[C:14]21[CH:20]([c:33]2[c:34]([F:44])[c:35]([F:43])[cH:36][cH:37][c:38]2[O:39][CH:40]([CH3:41])[CH3:42])[NH:21][C:22](=[O:32])[CH2:23][CH:24]1[c:25]1[cH:26][c:27]([Cl:31])[cH:28][cH:29][cH:30]1.[H-:45].[Li+:46]>>[CH3:1][O:2][CH:3]([CH3:4])[Si:5]([CH3:6])([CH3:7])[CH3:8].[Cl:9][c:10]1[cH:11][cH:12][c:13]2[c:17]([cH:18]1)[NH:16][C:15](=[O:19])[C:14]21[CH:20]([c:33]2[c:34]([F:44])[c:35]([F:43])[cH:36][cH:37][c:38]2[O:39][CH:40]([CH3:41])[CH3:42])[N:21]([CH2:50][CH2:49][CH2:48][Cl:47])[C:22](=[O:32])[CH2:23][CH:24]1[c:25]1[cH:26][c:27]([Cl:31])[cH:28][cH:29][cH:30]1

Participants

8

Reactant 6

HCID 6228DimethylformamideHCID 28486Lithium ionHCID 813631-Chloro-3-iodopropaneHCID 166653HydrideHCID 22400412(1-Methoxyethyl)(trimethyl)silaneHCID 743703736-chloro-4'-(3-chlorophenyl)-2'-(2,3-difluoro-6-isopropoxy-phenyl) spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Product 2

HCID 22400412(1-Methoxyethyl)(trimethyl)silaneHCID 775806576-chloro-4'-(3-chlorophenyl)-1'-(3-chloropropyl)-6'-(2,3-difluoro-6-propan-2-yloxyphenyl)spiro[1H-indole-3,5'-piperidine]-2,2'-dione

Sources & evidence

ORD record
ord-a50ef9cbebb949e190443eb8d0fd6f86
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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