Hydrochloric Acid → t-Butyl 3-(1-carboxycyclopentyl)propanoate

HRID 960487Notes

Reaction equation

HRID 960487 reaction equation
[Br:21][CH2:22][CH2:23][C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30].[CH3:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42].[CH3:43][CH2:44][O:45][CH2:46][CH3:47].[CH:13]1([C:18](=[O:19])[OH:20])[CH2:14][CH2:15][CH2:16][CH2:17]1.[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[ClH:31].[Li:8][CH2:9][CH2:10][CH2:11][CH3:12].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[C:13]1([C:18](=[O:19])[OH:20])([CH2:22][CH2:23][C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:14][CH2:15][CH2:16][CH2:17]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 8058HexaneHCID 18840Cyclopentanecarboxylic acidHCID 256128tert-Butyl 3-bromopropionateHCID 178418339Butyllithium

Product 1

HCID 11010130t-Butyl 3-(1-carboxycyclopentyl)propanoate

Sources & evidence

ORD record
ord-8f16ef15ba454adbbcba36815639643b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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