Hydrochloric Acid → trans-2-(4-Hydroxycyclohexyl)-isoindole-1,3-dione

HRID 960665Notes

Reaction equation

HRID 960665 reaction equation
[C:10]([N:11]1[C:16](=[O:25])[c:17]2[c:18]([cH:21][cH:22][cH:23][cH:24]2)[C:19]1=[O:20])([O:12][CH2:13][CH3:14])=[O:15].[C:26](=[O:27])([O-:28])[O-:29].[CH3:33][CH2:34][O:35][C:36](=[O:37])[CH3:38].[ClH:1].[NH2:2][CH:3]1[CH2:4][CH2:5][CH:6]([OH:9])[CH2:7][CH2:8]1.[Na+:30].[Na+:31].[OH2:32]>>[N:2]1([CH:3]2[CH2:4][CH2:5][CH:6]([OH:9])[CH2:7][CH2:8]2)[C:16](=[O:25])[c:17]2[c:18]([cH:21][cH:22][cH:23][cH:24]2)[C:19]1=[O:20]

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 923Sodium ion2×HCID 962WaterHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 31187N-CarbethoxyphthalimideHCID 812934-Aminocyclohexanol

Product 1

HCID 288726trans-2-(4-Hydroxycyclohexyl)-isoindole-1,3-dione

Sources & evidence

ORD record
ord-c9a89c0d2df14c78ab0065071bc8eb55
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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