1,2-Dichloroethane → tert-butyl N-[1-(3,4-difluorophenyl)-4-(6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl)-4-oxobutan-2-yl]carbamate

HRID 960789Notes

Reaction equation

HRID 960789 reaction equation
[CH2:51]([Cl:52])[CH2:53][Cl:54].[CH3:10][C:11]([CH3:12])([O:13][C:14](=[O:15])[NH:16][CH:17]([CH2:18][C:19](=[O:20])[OH:21])[CH2:22][c:23]1[cH:24][c:25]([F:30])[c:26]([F:29])[cH:27][cH:28]1)[CH3:31].[CH:32]([N:33]([CH2:34][CH3:35])[CH:36]([CH3:37])[CH3:38])([CH3:39])[CH3:40].[Cl:55][CH2:56][Cl:57].[OH:41][n:42]1[c:43]2[c:44]([cH:45][cH:46][cH:47][cH:48]2)[n:49][n:50]1.[n:1]1[cH:2][cH:3][n:4]2[c:5]1[CH2:6][NH:7][CH2:8][CH2:9]2>>[n:1]1[cH:2][cH:3][n:4]2[c:5]1[CH2:6][N:7]([C:19]([CH2:18][CH:17]([NH:16][C:14]([O:13][C:11]([CH3:10])([CH3:12])[CH3:31])=[O:15])[CH2:22][c:23]1[cH:24][c:25]([F:30])[c:26]([F:29])[cH:27][cH:28]1)=[O:20])[CH2:8][CH2:9]2

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 6344DichloromethaneHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 132470465,6,7,8-Tetrahydroimidazo(1,2-a)pyrazineHCID 219112153-(Boc-amino)-4-(3,4-difluorophenyl)butyric Acid

Product 1

HCID 77219236tert-butyl N-[1-(3,4-difluorophenyl)-4-(6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl)-4-oxobutan-2-yl]carbamate

Sources & evidence

ORD record
ord-b2cbdef7c54243949206f556c696b338
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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