Methanol → 4-[4-(3-Indolyl)piperidinomethyl]-2-propionylaminothiazole

HRID 961036Notes

Reaction equation

HRID 961036 reaction equation
[C:35]([CH2:36][CH3:37])(=[O:38])[Cl:39].[CH2:40]([Cl:41])[Cl:42].[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[CH3:30][N:31]([CH3:32])[CH:33]=[O:34].[CH3:47][OH:48].[CH:43]([Cl:44])([Cl:45])[Cl:46].[nH:1]1[cH:2][c:3]([CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][c:17]3[n:18][c:19]([NH2:22])[s:20][cH:21]3)[CH2:14][CH2:15]2)[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]12>>[nH:1]1[cH:2][c:3]([CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][c:17]3[n:18][c:19]([NH:22][C:35]([CH2:36][CH3:37])=[O:38])[s:20][cH:21]3)[CH2:14][CH2:15]2)[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]12

Participants

8

Reactant 7

HCID 887MethanolHCID 6212ChloroformHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 62324Propionyl chlorideHCID 141297964-((4-(1H-Indol-3-yl)piperidin-1-yl)methyl)thiazol-2-amine

Product 1

HCID 103169664-[4-(3-Indolyl)piperidinomethyl]-2-propionylaminothiazole

Sources & evidence

ORD record
ord-27a51e75d51d44258cc0a3c92ebd727b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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