Tetrahydrofuran → 3-(7-bromo-5-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-3H-imidazole-4-carboxylic acid isopropyl ester

HRID 961210Notes

Reaction equation

HRID 961210 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:13])[c:5]2[c:10]([cH:11]1)[CH:9]([OH:12])[CH2:8][CH2:7][CH2:6]2.[CH2:53]1[O:54][CH2:55][CH2:56][CH2:57]1.[N:44]([C:45]([O:46][CH3:47])=[O:48])=[N:49][C:50]([O-:51])=[O:52].[c:25]1([P:26]([c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[cH:39][cH:40][cH:41][cH:42][cH:43]1.[nH:14]1[cH:15][n:16][c:17]([C:19](=[O:20])[O:21][CH:22]([CH3:23])[CH3:24])[cH:18]1>>[Br:1][c:2]1[cH:3][c:4]([F:13])[c:5]2[c:10]([cH:11]1)[CH:9]([n:16]1[cH:15][n:14][cH:18][c:17]1[C:19](=[O:20])[O:21][CH:22]([CH3:23])[CH3:24])[CH2:8][CH2:7][CH2:6]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 675473967-bromo-5-fluoro-3,4-dihydro-2H-naphthalen-1-olHCID 86639266Methyl azodicarboxylateHCID 178459416HCID 178459416, compound

Product 1

HCID 591994533-(7-bromo-5-fluoro-1,2,3,4-tetrahydro-naphthalen-1-yl)-3H-imidazole-4-carboxylic acid isopropyl ester

Sources & evidence

ORD record
ord-34ce4cfc21324a38914bd6c9badf3ff4
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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