Chloride → Tert-butyl 2-(6-chloro-5-methylpyridin-3-yl)acetate

HRID 961432Notes

Reaction equation

HRID 961432 reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH3:9])[c:5]([Cl:8])[n:6][cH:7]1.[C:11]([CH3:12])([CH3:13])([CH3:14])[O:15][C:16]([CH2:17][Zn+:18])=[O:19].[CH2:20]1[O:21][CH2:22][CH2:23][CH2:24]1.[Cl-:10]>>[c:2]1([CH2:17][C:16]([O:15][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:19])[cH:3][c:4]([CH3:9])[c:5]([Cl:8])[n:6][cH:7]1

Participants

5

Reactant 4

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 2854345-Bromo-2-chloro-3-methylpyridineHCID 178451180HCID 178451180, compound

Product 1

HCID 58447848Tert-butyl 2-(6-chloro-5-methylpyridin-3-yl)acetate

Sources & evidence

ORD record
ord-fef4ea46560d4d5c86953c2dce2026cc
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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