Tetrahydrofuran → N-benzyl-2-(3-(2,2-dimethoxyethyl)-3-(4-fluorobenzyl)ureido)-4-methylthiazole-5-carboxamide

HRID 961508Notes

Reaction equation

HRID 961508 reaction equation
[C:18](=[O:19])([n:20]1[cH:21][cH:22][n:23][cH:24]1)[n:25]1[cH:26][cH:27][n:28][cH:29]1.[F:30][c:31]1[cH:32][cH:33][c:34]([CH2:35][NH:36][CH2:37][CH:38]([O:39][CH3:40])[O:41][CH3:42])[cH:43][cH:44]1.[NH2:1][c:2]1[s:3][c:4]([C:8](=[O:9])[NH:10][CH2:11][c:12]2[cH:13][cH:14][cH:15][cH:16][cH:17]2)[c:5]([CH3:7])[n:6]1.[O:45]1[CH2:46][CH2:47][CH2:48][CH2:49]1>>[NH:1]([c:2]1[s:3][c:4]([C:8](=[O:9])[NH:10][CH2:11][c:12]2[cH:13][cH:14][cH:15][cH:16][cH:17]2)[c:5]([CH3:7])[n:6]1)[C:18](=[O:19])[N:36]([CH2:35][c:34]1[cH:33][cH:32][c:31]([F:30])[cH:44][cH:43]1)[CH2:37][CH:38]([O:39][CH3:40])[O:41][CH3:42]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 682631,1'-CarbonyldiimidazoleHCID 210824N-Benzyl-2-imino-4-methyl-2,3-dihydro-1,3-thiazole-5-carboximidic acidHCID 11615438N-(2,2-dimethoxyethyl)-N-(4-fluorobenzyl)amine

Product 1

HCID 86645286N-benzyl-2-(3-(2,2-dimethoxyethyl)-3-(4-fluorobenzyl)ureido)-4-methylthiazole-5-carboxamide

Sources & evidence

ORD record
ord-29c97f153a5941f9b4e796ab824e4b1c
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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