Hydrochloric Acid → 4-Amino-5-(4-chloro-2-methoxy-benzoylamino)-pyrimidine

HRID 961751Notes

Reaction equation

HRID 961751 reaction equation
[CH3:45][N:46]([CH3:47])[c:48]1[cH:49][cH:50][n:51][cH:52][cH:53]1.[Cl:13][c:14]1[cH:15][cH:16][c:17]([C:18]([OH:19])=[O:20])[c:21]([O:22][CH3:23])[cH:24]1.[Cl:1][c:2]1[cH:3][c:4]([O:11][CH3:12])[c:5]([C:6](=[O:7])[Cl:8])[cH:9][cH:10]1.[ClH:29].[ClH:30].[NH2:31][c:32]1[n:33][cH:34][n:35][cH:36][c:37]1[NH2:38].[S:25]([Cl:26])([Cl:27])=[O:28].[cH:39]1[cH:40][cH:41][n:42][cH:43][cH:44]1>>[Cl:1][c:2]1[cH:3][c:4]([O:11][CH3:12])[c:5]([C:6](=[O:7])[NH:38][c:37]2[c:32]([NH2:31])[n:33][cH:34][n:35][cH:36]2)[cH:9][cH:10]1

Participants

8

Reactant 7

HCID 313Hydrochloric Acid2×HCID 1049PyridineHCID 142844-(Dimethylamino)pyridineHCID 24386Thionyl ChlorideHCID 837034,5-DiaminopyrimidineHCID 936824-Chloro-o-anisic acidHCID 221424504-Chloro-2-methoxybenzoyl chloride

Product 1

HCID 205627114-Amino-5-(4-chloro-2-methoxy-benzoylamino)-pyrimidine

Sources & evidence

ORD record
ord-29db4dca617b4a669653d84e52bdb957
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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