Methanol → 1-[3-[[4-Hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-[[4-(trifluoromethyl)pyridin-2-yl]methoxy]ethanone

HRID 961904Notes

Reaction equation

HRID 961904 reaction equation
[C:42]([O:43][BH-:44]([O:45][C:46](=[O:47])[CH3:48])[O:49][C:50](=[O:51])[CH3:52])(=[O:53])[CH3:54].[CH3:56][CH2:57][O:58][C:59]([CH3:60])=[O:61].[CH3:62][OH:63].[CH:64]([OH:65])([CH3:66])[CH3:67].[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:9][O:10][CH2:11][C:12](=[O:13])[N:14]2[CH2:15][CH:16]([NH2:19])[CH2:17][CH2:18]2)[n:6][cH:7][cH:8]1)([F:20])[F:21].[Na+:55].[OH:22][C:23]1([c:30]2[n:31][cH:32][c:33](-[c:36]3[n:37][cH:38][cH:39][cH:40][n:41]3)[cH:34][cH:35]2)[CH2:24][CH2:25][C:26](=[O:29])[CH2:27][CH2:28]1>>[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:9][O:10][CH2:11][C:12](=[O:13])[N:14]2[CH2:15][CH:16]([NH:19][CH:26]3[CH2:25][CH2:24][C:23]([OH:22])([c:30]4[n:31][cH:32][c:33](-[c:36]5[n:37][cH:38][cH:39][cH:40][n:41]5)[cH:34][cH:35]4)[CH2:28][CH2:27]3)[CH2:17][CH2:18]2)[n:6][cH:7][cH:8]1)([F:20])[F:21]

Participants

8

Reactant 7

HCID 887MethanolHCID 923Sodium ionHCID 3776IsopropanolHCID 8857Ethyl AcetateHCID 2724942TriacetoxyborohydrideHCID 578033584-Hydroxy-4-[5-(2-pyrimidinyl)-2-pyridyl]cyclohexanoneHCID 690056531-({[4-(Trifluoromethyl)pyridin-2-yl]methoxy}acetyl)pyrrolidin-3-amine

Product 1

HCID 578032941-[3-[[4-Hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-[[4-(trifluoromethyl)pyridin-2-yl]methoxy]ethanone

Sources & evidence

ORD record
ord-8e1196a52228407897bb82641b20db9e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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