→ Ethyl 6-methyl-2-oxo-4-(thiophen-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

HRID 962316Notes

Reaction equation

HRID 962316 reaction equation
CC(=O)O.CCO.CCOC(=O)CC(C)=O.NC(N)=O.O.O=Cc1cccs1.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3]>>CCOC(=O)C1=C(C)NC(=O)NC1c1cccs1

Participants

7

Reactant 0

No Reactant data yet.

Product 1

HCID 332931Ethyl 6-methyl-2-oxo-4-(thiophen-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylateYield 89%

Reagents, catalysts & solvents 6

HCID 176Acetic AcidOtherHCID 702EthanolOtherHCID 1176UreaOtherHCID 73642-ThiophenecarboxaldehydeOtherHCID 8868Ethyl AcetoacetateOtherHCID 45075687Ytterbium(3+) trifluoromethanesulfonate--water (1/3/1)Other

Conditions

Temperature
120 °C

Workup

  1. waitNo procedure recorded
  2. filtrationKeep solid
  3. washNo procedure recorded
  4. dry in vacuumNo procedure recorded

Sources & evidence

ORD record
ord-a9b0911c127d4ecca76d79d7a78566e6
Source dataset
Microwave-assisted Biginelli Condensation Dataset
Original link
View source

Reaction notes

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