HCID 70210346, compound → HCID 70210143, compound

HRID 962406Notes

Reaction equation

HRID 962406 reaction equation
Cl.[P:2]([C:6]1([C:15]([OH:17])=[O:16])[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][CH2:11][NH:12]2)=[CH:7]1)([OH:5])([OH:4])=[O:3]>O.O=[Pt]=O>[P:2]([C:6]1([C:15]([OH:17])=[O:16])[CH2:14][CH:13]2[CH:8]([CH2:9][CH2:10][CH2:11][NH:12]2)[CH2:7]1)([OH:4])([OH:5])=[O:3]

Participants

4

Reactant 1

HCID 70210346HCID 70210346, compound

Product 1

HCID 70210143HCID 70210143, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 962WaterSolvent

Procedure

1.0 g of dihydro-6-phosphono-1-pyrindine-6-carboxylic acid hydrochloride (Example 31) in 50 ml of H2O with 0.5 g of PtO2 is hydrogenated on a Parr apparatus at 40 PSI and 50° for 3 days. The catalyst is filtered off, and the filtrate is taken to dryness under vacuum. The resulting solid is taken up in the minimum amount of water, and precipitated by slow addition of ethanol to give octahydro-6-phosphono-1-pyrindine-6-carboxylic acid.

Workup

  1. filtrationThe catalyst is filtered off
  2. customprecipitated by slow addition of ethanol

Sources & evidence

ORD record
ord-04c173b840fa45979db11efff6b313a7
Source dataset
uspto-grants-1998_06
Patent number
US05760021

Reaction notes

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