HCID 70210107, compound → HCID 86752683, compound

HRID 962407Notes

Reaction equation

HRID 962407 reaction equation
[I-].[C:2]([C:5]1([P:15]([OH:18])([OH:17])=[O:16])[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][CH2:10][NH+:11]2[CH3:14])=[CH:6]1)([OH:4])=[O:3]>O.O=[Pt]=O>[CH3:14][N:11]1[CH:12]2[CH:7]([CH2:6][C:5]([P:15]([OH:18])([OH:17])=[O:16])([C:2]([OH:4])=[O:3])[CH2:13]2)[CH2:8][CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 70210107HCID 70210107, compound

Product 1

HCID 86752683HCID 86752683, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 962WaterSolvent

Procedure

A suspension of 2.0 g of dihydro-6-carboxy-1-methyl-6-phosphono-1-pyrindinium iodide (Example 32) and 1.0 g of PtO2 in 50 ml of water is hydrogenated at 40 PSI and 50° for 2 days on a Parr apparatus. After the catalyst is removed by filtration, the filtrate is evaporated to dryness. The residue is recrystallized from water/acetone to yield octahydro-1-methyl-6-phosphono-1-pyrindine-6-carboxylic acid.

Workup

  1. customAfter the catalyst is removed by filtration
  2. customthe filtrate is evaporated to dryness
  3. customThe residue is recrystallized from water/acetone

Sources & evidence

ORD record
ord-ffeac83f4a174ba0aadf87f5950bf46b
Source dataset
uspto-grants-1998_06
Patent number
US05760021

Reaction notes

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