Triethylamine → HCID 19085499, compound

HRID 962438Notes

Reaction equation

HRID 962438 reaction equation
CN(C[N:5]=[CH:6][CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)C.[F:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22]Br)=[CH:16][CH:15]=1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[NH2:5][CH2:6][CH:7]1[CH2:8][CH2:9][N:10]([CH2:22][CH2:21][O:20][C:17]2[CH:18]=[CH:19][C:14]([F:13])=[CH:15][CH:16]=2)[CH2:11][CH2:12]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 20641711-(2-Bromoethoxy)-4-fluorobenzeneHCID 57180202HCID 57180202, compound

Product 1

HCID 19085499HCID 19085499, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In a similar manner to Example 3, a mixture of 4-(dimethylaminomethyliminomethyl)piperidine (6.42 g), 2-bromoethyl 4-fluorophenyl ether (8.3 g), triethylamine (5.3 ml) and toluene (20 ml) was heated on a steam bath for 16 hours to give 4-aminomethyl-1-[2-(4-fluorophenoxy)ethyl]piperidine as an oil.

Workup

  1. temperaturewas heated on a steam bath for 16 hours

Sources & evidence

ORD record
ord-86807b1052254b4099cce46545d4aecd
Source dataset
uspto-grants-1998_06
Patent number
US05760035

Reaction notes

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