Hydrochloric Acid → HCID 86752685, compound

HRID 962477Notes

Reaction equation

HRID 962477 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:20][O:21][CH:22]([C:27]2[CH:32]=[C:31]([C:33]([F:36])([F:35])[F:34])[CH:30]=[C:29]([C:37]([F:40])([F:39])[F:38])[CH:28]=2)[C:23]([O:25][CH3:26])=[O:24])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:41]>>[ClH:41].[C:14]1([C:11]2([CH2:20][O:21][CH:22]([C:27]3[CH:32]=[C:31]([C:33]([F:34])([F:35])[F:36])[CH:30]=[C:29]([C:37]([F:40])([F:38])[F:39])[CH:28]=3)[C:23]([O:25][CH3:26])=[O:24])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 10626973HCID 10626973, compound

Product 1

HCID 86752685HCID 86752685, compound

Procedure

The product of step (c) above was dissolved in saturated methanolic hydrogen chloride, and allowed to stand at room temperature for 24 hours. The solvents were evaporated at reduced pressure then toluene was added to the residue and evaporated at reduced pressure to afford the title compound as a colourless foam. Analysis Calcd. for C23H23 F6NO3.HCl. 0.5(H2O): C, 53.03; H, 4.84; N, 2.69; Found: C, 52.78; H, 4.75; N, 2.75%. MS (Cl+) 476 (M+H)+.

Workup

  1. customThe solvents were evaporated at reduced pressure
  2. additiontoluene was added to the residue
  3. customevaporated at reduced pressure

Sources & evidence

ORD record
ord-e50556aa55ec48218ee16634466f8e9b
Source dataset
uspto-grants-1998_06
Patent number
US05760018

Reaction notes

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